Smart Manufacturing—Theories, Methods, and Applications

(First paragraph) Smart manufacturing (SM) distinguishes itself from other system paradigms by introducing ‘smartness’ as a measure to a manufacturing system; however, researchers in different domains have different expectations of system smartness from their own perspectives. In this Special Issue (SI), SM refers to a system paradigm where digital technologies are deployed to enhance system smartness by (1) empowering physical resources in production, (2) utilizing virtual and dynamic assets over the internet to expand system capabilities, (3) supporting data-driven decision making at all domains and levels of businesses, or (4) reconfiguring systems to adapt changes and uncertainties in dynamic environments. System smartness is measured by one or a combination of system performance metrics, such as the degree of automation, cost-effectiveness, leanness, robustness, flexibility, adaptability, sustainability, and resilience. This SI aims to present the most representative works in advancing the theories, methods, and applications of SM

Launch Editorial

The digital economy is first and foremost a data economy, and data is the first element of the digital economy. Management System Engineering (MSE) is dedicated to the methodology of System Engineering (SE) and the practice of Management Decision Making. The digital economy is a network economy, and the Internet is the basic carrier of the digital economy. [Extracted from the article

Research on Cutting Force of Turn-Milling Based on Thin-Walled Blade

Turn-milling is regarded as the milling of a curved surface while rotating the workpiece around its center point, which combines effectively the advantages of both turning and milling, wherein it allows for good metal removal with the difficult-to-cut thin-walled workpieces in aviation. The objective of the present work is to study cutting force by turn-milling in cutting condition. Aiming at the deformation properties of thin-walled blade, the predicted models of rigid cutting force and flexible cutting force with ball cutter are provided, respectively, in turn-milling process. The deformation values of blade and cutter are calculated, respectively, based on the engaged trajectory by using the iterative algorithm. The rigid and flexible cutting forces are compared and the influence degrees of cutting parameters on cutting forces are analyzed. These conclusions provide theoretical foundation and reference for turn-milling mechanism research

Semantic Inference on Clinical Documents: Combining Machine Learning Algorithms With an Inference Engine for Effective Clinical Diagnosis and Treatment

Clinical practice calls for reliable diagnosis and optimized treatment. However, human errors in health care remain a severe issue even in industrialized countries. The application of clinical decision support systems (CDSS) casts light on this problem. However, given the great improvement in CDSS over the past several years, challenges to their wide-scale application are still present, including: 1) decision making of CDSS is complicated by the complexity of the data regarding human physiology and pathology, which could render the whole process more time-consuming by loading big data related to patients; and 2) information incompatibility among different health information systems (HIS) makes CDSS an information island, i.e., additional input work on patient information might be required, which would further increase the burden on clinicians. One popular strategy is the integration of CDSS in HIS to directly read electronic health records (EHRs) for analysis. However, gathering data from EHRs could constitute another problem, because EHR document standards are not unified. In addition, HIS could use different default clinical terminologies to define input data, which could cause additional misinterpretation. Several proposals have been published thus far to allow CDSS access to EHRs via the redefinition of data terminologies according to the standards used by the recipients of the data flow, but they mostly aim at specific versions of CDSS guidelines. This paper views these problems in a different way. Compared with conventional approaches, we suggest more fundamental changes; specifically, uniform and updatable clinical terminology and document syntax should be used by EHRs, HIS, and their integrated CDSS. Facilitated data exchange will increase the overall data loading efficacy, enabling CDSS to read more information for analysis at a given time. Furthermore, a proposed CDSS should be based on self-learning, which dynamically updates a knowledge model according to the data-stream-based upcoming data set. The experiment results show that our system increases the accuracy of the diagnosis and treatment strategy designs

Generic Design Methodology for Smart Manufacturing Systems from a Practical Perspective, Part I—Digital Triad Concept and Its Application as a System Reference Model

Rapidly developed information technologies (IT) have continuously empowered manufacturing systems and accelerated the evolution of manufacturing system paradigms, and smart manufacturing (SM) has become one of the most promising paradigms. The study of SM has attracted a great deal of attention for researchers in academia and practitioners in industry. However, an obvious fact is that people with different backgrounds have different expectations for SM, and this has led to high diversity, ambiguity, and inconsistency in terms of definitions, reference models, performance matrices, and system design methodologies. It has been found that the state of the art SM research is limited in two aspects: (1) the highly diversified understandings of SM may lead to overlapped, missed, and non-systematic research efforts in advancing the theory and methodologies in the field of SM; (2) few works have been found that focus on the development of generic design methodologies for smart manufacturing systems from the practice perspective. The novelty of this paper consists of two main aspects which are reported in two parts respectively. In the first part, a simplified definition of SM is proposed to unify the existing diversified expectations, and a newly developed concept named digital triad (DT-II) is adopted to define a reference model for SM. The common features of smart manufacturing systems in various applications are identified as functional requirements (FRs) in systems design. To model a system that is capable of reconfiguring itself to adapt to changes, the concept of IoDTT is proposed as a reference model for smart manufacturing systems. In the second part, these two concepts are used to formulate a system design problem, and a generic methodology, based on axiomatic design theory (ADT), is proposed for the design of smart manufacturing systems

Generic Design Methodology for Smart Manufacturing Systems From a Practical Perspective. Part II—Systematic Designs of Smart Manufacturing Systems

In a traditional system paradigm, an enterprise reference model provides the guide for practitioners to select manufacturing elements, configure elements into a manufacturing system, and model system options for evaluation and comparison of system solutions against given performance metrics. However, a smart manufacturing system aims to reconfigure different systems in achieving high-level smartness in its system lifecycle; moreover, each smart system is customized in terms of the constraints of manufacturing resources and the prioritized performance metrics to achieve system smartness. Few works were found on the development of systematic methodologies for the design of smart manufacturing systems. The novel contributions of the presented work are at two aspects: (1) unified definitions of digital functional elements and manufacturing systems have been proposed; they are generalized to have all digitized characteristics and they are customizable to any manufacturing system with specified manufacturing resources and goals of smartness and (2) a systematic design methodology has been proposed; it can serve as the guide for designs of smart manufacturing systems in specified applications. The presented work consists of two separated parts. In the first part of paper, a simplified definition of smart manufacturing (SM) is proposed to unify the diversified expectations and a newly developed concept digital triad (DT-II) is adopted to define a generic reference model to represent essential features of smart manufacturing systems. In the second part of the paper, the axiomatic design theory (ADT) is adopted and expanded as the generic design methodology for design, analysis, and assessment of smart manufacturing systems. Three case studies are reviewed to illustrate the applications of the proposed methodology, and the future research directions towards smart manufacturing are discussed as a summary in the second part

Following an environmental carcinogen N2-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase

We have investigated how a benzo[a]pyrene-derived N2-dG adduct, 10S(+)-trans-anti-[BP]-N2-dG ([BP]G*), is processed in a well-characterized Pol I family model replicative DNA polymerase, Bacillus fragment (BF). Experimental results are presented that reveal relatively facile nucleotide incorporation opposite the lesion, but very inefficient further extension. Computational studies follow the possible bypass of [BP]G* through the pre-insertion, insertion and post-insertion sites as BF alternates between open and closed conformations. With dG* in the normal B-DNA anti conformation, BP seriously disturbs the polymerase structure, positioning itself either deeply in the pre-insertion site or on the crowded evolving minor groove side of the modified template, consistent with a polymerase-blocking conformation. With dG* in the less prevalent syn conformation, BP causes less distortion: it is either out of the pre-insertion site or in the major groove open pocket of the polymerase. Thus, the syn conformation can account for the observed relatively easy incorporation of nucleotides, with mutagenic purines favored, opposite the [BP]G* adduct. However, with the lesion in the BF post-insertion site, more serious distortions caused by the adduct even in the syn conformation explain the very inefficient extension observed experimentally. In vivo, a switch to a potentially error-prone bypass polymerase likely dominates translesion bypass